Greek scientist finds the way to revert cancerous cells to healthy tissue
“The study brings together two so-far unrelated research fields — cell-to-cell adhesion and miRNA biology — to resolve a long-standing problem about the role of adhesion proteins in cell behavior that was baffling scientists,” says the study’s lead author Antonis Kourtidis, Ph.D., a research associate in Dr. Anastasiadis’ lab. “Most significantly, it uncovers a new strategy for cancer therapy,” he adds.
However, the tests have only been carried out in a test tube so it remains unclear whether the results can be replicated in people and if so, it is thought patients would still require chemotherapy.
“By administering the affected microRNAs in cancer cells to restore their normal levels, we should be able to re-establish the brakes and restore normal cell function. Initial experiments in some aggressive types of cancer are indeed very promising.” Dr Anastasiadis told the BBC.
The laboratory of Panagiotis (Panos) Z. Anastasiadis, Ph.D., is interested in elucidating the role of cadherin adhesion receptors, polarity proteins and Rho GTPases in human cancer. In particular, the lab is investigating adhesion-mediated signaling events that regulate cell growth, suppress cell motility and invasiveness, and promote the reorganization of the actin cytoskeleton.